I think we already support some CDN's but will have to get back to you on the specifics (not on my work computer and I don't want to give you the wrong info) I know we have worked with users with cloudflare before so you might try them. They have great support (who help out in here from time to time - Thanks guys!)
I honestly don't think that you should have issues with w3tc either, but I'm partial to our product. :)
Did I answer your original question?
Thanks!
tim